Whitehead Institute for Biomedical Research is a non-profit research institute located in Cambridge, Massachusetts, United States that is dedicated to improving human health through basic biomedical research. It was founded as a fiscally independent entity from the Massachusetts Institute of Technology (MIT), where its 19 members all hold faculty appointments in the MIT Department of Biology or the MIT Department of Bioengineering. As of 2025, Ruth Lehmann is its director, succeeding David C. Page in 2020.