Wayne Junction station is a SEPTA Regional Rail junction station located at 4481 Wayne Avenue, extending along Windrim Avenue to Germantown Avenue. The station is located in the Nicetown neighborhood of Philadelphia. Wayne Junction serves as a multi-modal transfer point between five of SEPTA's regional rail lines as well as 4 major transit routes – the Route 75 Trackless Trolley and Routes 2, 23 and 53. Routes 71 & 81 also operate express bus services here, but do not have a stop. The station served more than 321,000 riders annually in 2018.