Tissue remodeling is the reorganization or renovation of existing tissues. Tissue remodeling can be either physiological or pathological. The process of remodeling is generally intended to be the change microscopic properties of a tissue. Remodeling has often the function of optimizing the mechanical properties of the tissue reacting to external stimulus and adapting to it, as it is the case of bone and blood vessel remodeling. Other important examples of tissue that undergo remodeling include: connective tissue under tension or that is undergoing wound healing, during which the Macrophages remodel the tissue by producing extracellular matrix and proteases to modify that specific matrix.