The Santa Cruz Formation is a geological formation in the Magallanes/Austral Basin in southern Patagonia in Argentina and adjacent areas of Chile. It dates to the late Early Miocene epoch, and is contemporaneous with the eponymous Santacrucian age of the SALMA timescale. The Santa Cruz Formation is known for its abundance of vertebrate fossils, including South American native ungulates, as well as rodents, xenarthrans, and metatherians.