Plotkin's Vaccines is a comprehensive medical textbook on vaccines first published by American virologist Stanley Plotkin in 1988, that edition being co-authored by pediatrician and epidemiologist Edward A. Mortimer Jr., with subsequent editions produced every several years leading to the eighth edition in 2023. The seventh and eighth editions were co-authored by Plotkin, Paul Offit, Walter Orenstein, and Kathryn M. Edwards. The book is generally considered to be the standard reference in the field of vaccinology.