Kalamazoo County is a county located in the U.S. state of Michigan. As of 2020, the population was 261,670. The county seat is Kalamazoo. Kalamazoo County is included in the Kalamazoo–Portage MI Metropolitan Statistical Area. 2015 estimates placed the metropolitan statistical area as the 151st largest among similarly designated areas in the United States. 2015 estimates place the combined statistical area 85th among similarly designated areas.