Interstate 990 (I-990) is an auxiliary Interstate Highway located entirely within the town of Amherst in Erie County, New York, in the United States. It runs in a roughly north–south direction for 6.35 miles (10.22 km) through the southwestern and central parts of Amherst from an interchange with I-290 north of Buffalo to an intersection with New York Route 263 south of Lockport. The highway serves as a connection between Buffalo, the University at Buffalo, and Lockport. Like I-590 in nearby Rochester, I-990 does not physically meet I-90, its parent Interstate Highway; instead, the highway makes the connection by way of a "sibling" highway (I-290). As Interstates 91–99 do not have any 99x-numbered spurs, I-990 is the highest numbered Interstate Highway in the US.