Estradiol enanthate, also spelled estradiol enantate and sold under the brand names Perlutal and Topasel among others, is an estrogen medication which is used in hormonal birth control for women. It is formulated in combination with dihydroxyprogesterone acetophenide, a progestin, and is used specifically as a combined injectable contraceptive. Estradiol enanthate is not available for medical use alone. The medication, in combination with DHPA, is given by injection into muscle once a month.