The Dominickers were a small biracial ethnic group located within the Florida Panhandle, centered near the town of Ponce de Leon in Holmes County, Florida. Members of the group descended from a single interracial marriage during the Antebellum period, and were of generationally mixed African American and European American ancestry. The group became well known locally, to the extent that Dominicker and Dominickers became regional terms for people of mixed race. During the 20th century, academics classified them among 200 presumed "racial isolates" along groups such as the Redbones and Melungeons.