BETA SAÚDE

CLDN3

Texto da Wikipédia (en), licença CC BY-SA. O BETARUBI mostra o verbete inteiro nesta página — a leitura não continua fora do site.

CLDN3

Identifiers

Aliases

CLDN3, C7orf1, CPE-R2, CPETR2, HRVP1, RVP1, claudin 3

External IDs

OMIM: 602910; MGI: 1329044; GeneCards: CLDN3

Gene location (Human)

Chr.	Chromosome 7 (human)^[1]

Band	7q11.23	Start	73,768,997 bp^[1]
Band	7q11.23	End	73,770,270 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5 G2\|5 74.93 cM	Start	135,015,068 bp^[2]
Band	5 G2\|5 74.93 cM	End	135,016,326 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

mucosa of transverse colon

right uterine tube

mucosa of sigmoid colon

mucosa of ileum

left lobe of thyroid gland

bronchial epithelial cell

right lobe of thyroid gland

olfactory zone of nasal mucosa

body of pancreas

jejunal mucosa

Top expressed in

large intestine

left colon

crypt of lieberkuhn of small intestine

vestibular membrane of cochlear duct

jejunum

vestibular sensory epithelium

seminal vesicula

lacrimal gland

duodenum

left lung

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transmembrane signaling receptor activity structural molecule activity identical protein binding
Cellular component	membrane integral component of membrane cell junction apicolateral plasma membrane plasma membrane integral component of plasma membrane lateral plasma membrane bicellular tight junction cytoplasm
Biological process	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules response to hypoxia protein homooligomerization epithelial cell morphogenesis protein heterooligomerization bicellular tight junction assembly signal transduction response to ethanol
Sources:Amigo / QuickGO

Orthologs

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse

Entrez


1365


12739

Ensembl


ENSG00000165215


ENSMUSG00000070473

UniProt


O15551


Q9Z0G9

RefSeq (mRNA)


NM_001306


NM_009902

RefSeq (protein)


NP_001297


NP_034032

Location (UCSC)

Chr 7: 73.77 – 73.77 Mb

Chr 5: 135.02 – 135.02 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Claudin 3, also known as CLDN3, is a protein which in humans is encoded by the CLDN3 gene.^[5] It is a member of the claudin protein family.

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this intron-less gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is also a low-affinity receptor for Clostridium perfringens enterotoxin, and shares amino acid sequence similarity with a putative apoptosis-related protein found in rat.^[5]

Interactions

CLDN3 has been shown to interact with CLDN1^[6] and CLDN5.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165215 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070473 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CLDN3 claudin 3".
1 2 Coyne CB, Gambling TM, Boucher RC, Carson JL, Johnson LG (Nov 2003). "Role of claudin interactions in airway tight junctional permeability". Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5): L1166-78. doi:10.1152/ajplung.00182.2003. PMID 12909588.

External links

Human CLDN3 genome location and CLDN3 gene details page in the UCSC Genome Browser.
Overview of all the structural information available in the PDB for UniProt: Q9Z0G9 (Mouse Claudin-3) at the PDBe-KB.

Kniesel U, Wolburg H (2000). "Tight junctions of the blood-brain barrier". Cell. Mol. Neurobiol. 20 (1): 57–76. doi:10.1023/A:1006995910836. PMC 11537529. PMID 10690502. S2CID 26473781.
Heiskala M, Peterson PA, Yang Y (2001). "The roles of claudin superfamily proteins in paracellular transport". Traffic. 2 (2): 93–8. doi:10.1034/j.1600-0854.2001.020203.x. PMID 11247307.
Tsukita S, Furuse M, Itoh M (2001). "Multifunctional strands in tight junctions". Nat. Rev. Mol. Cell Biol. 2 (4): 285–93. doi:10.1038/35067088. PMID 11283726. S2CID 36524601.
Tsukita S, Furuse M (2002). "Claudin-based barrier in simple and stratified cellular sheets". Curr. Opin. Cell Biol. 14 (5): 531–6. doi:10.1016/S0955-0674(02)00362-9. PMID 12231346.
González-Mariscal L, Betanzos A, Nava P, Jaramillo BE (2003). "Tight junction proteins". Prog. Biophys. Mol. Biol. 81 (1): 1–44. doi:10.1016/S0079-6107(02)00037-8. PMID 12475568.
Katahira J, Sugiyama H, Inoue N, Horiguchi Y, Matsuda M, Sugimoto N (1997). "Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo". J. Biol. Chem. 272 (42): 26652–8. doi:10.1074/jbc.272.42.26652. PMID 9334247.
Peacock RE, Keen TJ, Inglehearn CF (1997). "Analysis of a human gene homologous to rat ventral prostate.1 protein". Genomics. 46 (3): 443–9. doi:10.1006/geno.1997.5033. PMID 9441748.
Morita K, Furuse M, Fujimoto K, Tsukita S (1999). "Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands". Proc. Natl. Acad. Sci. U.S.A. 96 (2): 511–6. Bibcode:1999PNAS...96..511M. doi:10.1073/pnas.96.2.511. PMC 15167. PMID 9892664.
Furuse M, Sasaki H, Tsukita S (1999). "Manner of interaction of heterogeneous claudin species within and between tight junction strands". J. Cell Biol. 147 (4): 891–903. doi:10.1083/jcb.147.4.891. PMC 2156154. PMID 10562289.
Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (1999). "Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins". J. Cell Biol. 147 (6): 1351–63. doi:10.1083/jcb.147.6.1351. PMC 2168087. PMID 10601346.
Miyamori H, Takino T, Kobayashi Y, Tokai H, Itoh Y, Seiki M, Sato H (2001). "Claudin promotes activation of pro-matrix metalloproteinase-2 mediated by membrane-type matrix metalloproteinases". J. Biol. Chem. 276 (30): 28204–11. doi:10.1074/jbc.M103083200. hdl:2297/15688. PMID 11382769.
Long H, Crean CD, Lee WH, Cummings OW, Gabig TG (2001). "Expression of Clostridium perfringens enterotoxin receptors claudin-3 and claudin-4 in prostate cancer epithelium". Cancer Res. 61 (21): 7878–81. PMID 11691807.
Katoh M, Katoh M (2003). "CLDN23 gene, frequently down-regulated in intestinal-type gastric cancer, is a novel member of CLAUDIN gene family". Int. J. Mol. Med. 11 (6): 683–9. doi:10.3892/ijmm.11.6.683. PMID 12736707.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS (2015). "A systems proteomics view of the endogenous human claudin protein family". J Proteome Res. 15 (2): 339–359. doi:10.1021/acs.jproteome.5b00769. PMC 4777318. PMID 26680015.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

A carregar…

CLDN3

Interactions

References

External links

Further reading