Alclofenac is a non-steroidal anti-inflammatory drug (NSAID) of the arylacetic acid class, that was mainly used for rheumatic disorders, such as rheumatoid arthritis, degenerative joint disease, and ankylosing spondylitis. It exhibits anti‑inflammatory, analgesic, and antipyretic properties primarily through reversible inhibition of cyclooxygenase (COX) enzymes and subsequent suppression of prostaglandin synthesis. However, it has largely fallen into disuse in favour of safer alternatives such as aceclofenac and was even withdrawn from multiple countries’ markets due to concerns about some of its side effects.