"A Hard Day's Night" is the pilot episode and series premiere of the American television medical drama Grey's Anatomy, which first aired on March 27, 2005 on ABC. The episode introduces the main characters and surgical interns Meredith Grey, Cristina Yang, Izzie Stevens, George O'Malley, and Alex Karev, as they begin their journey into the world of surgery at Seattle Grace Hospital. Other key characters introduced in the episode include Derek Shepherd, Miranda Bailey, Richard Webber and Preston Burke.