Tychism is a thesis proposed by the American philosopher Charles Sanders Peirce that holds that absolute chance, or indeterminism, is a real factor operative in the universe. This doctrine forms a central part of Peirce's comprehensive evolutionary cosmology. It may be considered both the direct opposite of Albert Einstein's oft quoted dictum that: "God does not play dice with the universe" and an early philosophical anticipation of Werner Heisenberg's uncertainty principle.