The Pfizer Building is a skyscraper on 42nd Street in the East Midtown neighborhood of Manhattan, New York City, New York, U.S. The structure consists of two formerly separate buildings at 219 and 235 East 42nd Street, which housed the pharmaceutical company Pfizer. The older building at 219 East 42nd Street, completed in 1905, was originally a 10-story building. The building at 235 East 42nd Street, designed by Emery Roth & Sons in the International Style, was constructed in 1960 and has 33 stories.