PIK3R6
Identifiers
Aliases	PIK3R6, C17orf38, HsT41028, p84 PIKAP, p87(PIKAP), p87PIKAP, phosphoinositide-3-kinase regulatory subunit 6
External IDs	OMIM: 611462; MGI: 2144613; GeneCards: PIK3R6
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 8,802,722 bp[1] End 8,867,677 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B3 Start 68,393,845 bp[2] End 68,443,524 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte testicle spleen appendix apex of heart blood gonad gallbladder lymph node Top expressed in granulocyte carotid body renal corpuscle lumbar spinal ganglion bone marrow Paneth cell morula substantia nigra central gray substance of midbrain nucleus of stria terminalis More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1-phosphatidylinositol-3-kinase regulator activity Cellular component cytoplasm cytosol plasma membrane phosphatidylinositol 3-kinase complex, class IB membrane phosphatidylinositol 3-kinase complex Biological process platelet activation positive regulation of T cell differentiation phosphatidylinositol phosphate biosynthetic process regulation of phosphatidylinositol 3-kinase activity angiogenesis positive regulation of angiogenesis regulation of natural killer cell mediated cytotoxicity phosphatidylinositol 3-kinase signaling positive regulation of MAP kinase activity G protein-coupled receptor signaling pathway phosphatidylinositol biosynthetic process Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 146850 104709 Ensembl ENSG00000276231 ENSMUSG00000046207 UniProt Q5UE93 Q3U6Q4 RefSeq (mRNA) NM_001010855 NM_001290211 NM_001004435 NM_001081566 RefSeq (protein) NP_001010855 NP_001277140 NP_001004435 NP_001075035 Location (UCSC) Chr 17: 8.8 – 8.87 Mb Chr 11: 68.39 – 68.44 Mb PubMed search [3] [4]
Wikidata
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Phosphoinositide 3-kinase regulatory subunit 6 (also called p87^PIKAP) is a protein that in humans is encoded by the PIK3R6 gene.^[5] The PIK3R6 protein is a regulatory subunit of phosphoinositide 3-kinase-γ (PI3Kγ), which functions as an enzyme (a lipid kinase) that is activated by membrane receptors.^[5] PIK3R6 is highly expressed in the heart and is present in dendritic cells, macrophages, and neutrophils.^[6] It is also referred to as p84 and p87.^[7] Some studies have found PIK3R6 to have a role in carcinogenesis.^[8]

References

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