NCALD
Identifiers
Aliases	NCALD, neurocalcin delta
External IDs	OMIM: 606722; MGI: 1196326; GeneCards: NCALD
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1BJF
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.3 Start 101,686,542 bp[1] End 102,124,907 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 14.94 cM Start 37,366,175 bp[2] End 37,792,570 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 frontal pole primary visual cortex orbitofrontal cortex Brodmann area 46 middle temporal gyrus dorsolateral prefrontal cortex right frontal lobe Brodmann area 23 superior frontal gyrus Top expressed in lateral septal nucleus dentate gyrus dentate gyrus of hippocampal formation granule cell primary motor cortex ventromedial nucleus visual cortex primary visual cortex amygdala prefrontal cortex piriform cortex More reference expression data BioGPS n/a
Gene ontology Molecular function tubulin binding clathrin binding calcium ion binding actin binding alpha-tubulin binding protein binding metal ion binding ligand-gated ion channel activity Cellular component cytosol intracellular anatomical structure clathrin coat of trans-Golgi network vesicle Biological process vesicle-mediated transport calcium-mediated signaling regulation of systemic arterial blood pressure ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 83988 52589 Ensembl ENSG00000104490 ENSMUSG00000051359 UniProt P61601 Q91X97 RefSeq (mRNA) NM_001040624 NM_001040625 NM_001040626 NM_001040627 NM_001040628 NM_001040629 NM_001040630 NM_032041 NM_001170866 NM_001170867 NM_001170868 NM_134094 NM_001359839 NM_001359840 NM_001359841 NM_001359842 NM_001359843 NM_001359844 NM_001359845 RefSeq (protein) NP_001035714 NP_001035715 NP_001035716 NP_001035717 NP_001035718 NP_001035719 NP_001035720 NP_114430 NP_001164337 NP_001164338 NP_001164339 NP_598855 NP_001346768 NP_001346769 NP_001346770 NP_001346771 NP_001346772 NP_001346773 NP_001346774 Location (UCSC) Chr 8: 101.69 – 102.12 Mb Chr 15: 37.37 – 37.79 Mb PubMed search [3] [4]
Wikidata
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neurocalcin delta
Identifiers
Symbol	NCALD
NCBI gene	83988
HGNC	7655
OMIM	606722
RefSeq	NM_001040628
UniProt	P61601
Other data
Locus	Chr. 8 q22-q23
Search for Structures Swiss-model Domains InterPro

Neurocalcin delta is a neuronal calcium-binding protein which in humans is encoded by the NCALD gene. Neurocalcin belongs to the neuronal calcium sensor (NCS) family of proteins.^[5][6] It expressed in mammalian brains. It possesses a Ca²⁺/myristoyl switch

The subclass of neurocalcins are brain-specific proteins that fit into the EF-hand superfamily of calcium binding proteins. The NCS family were defined by the photoreceptor cell-specific protein, recoverin. Neurocalcin was purified from the bovine brain by using calcium-dependent drug affinity chromatography. The amino acid sequence showed that neurocalcin has three functional calcium binding sites. It is expressed in the central nervous system, retina, and adrenal gland. With this unique pattern of expression it is thought that neurcalcin offers a different physiological role than similar proteins visinin and recoverin.

Neurocalcin delta an isoform of Neurocalcin is known to regulate adult neurogenesis.^[7]

References

Further reading

External links

• Neurocalcin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• NCS proteins
• Protein Database Page

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