JAMA is a peer-reviewed medical journal published 48 times a year by the American Medical Association. It publishes original research, reviews, and editorials covering all aspects of biomedicine. The journal was established in 1883 with Nathan Smith Davis as the founding editor. Its publisher describes it as the most widely circulated general medical journal in the world, with more than 101,000 print recipients, more than 2.9 million recipients of electronic tables of contents and alerts, and over 29 million annual website visits. Kirsten Bibbins-Domingo of the University of California, San Francisco became the journal editor-in-chief on July 1, 2022, succeeding Howard Bauchner of Boston University.