Hartwell is one of the 52 neighborhoods of Cincinnati, Ohio. Established in 1868 and annexed in 1912, it is the city's northernmost neighborhood, centered roughly on the intersections of I-75 and Ronald Reagan Cross County Highway. Its boundaries are a combination of Caldwell Park and Ronald Reagan Cross County Highway to the south, I-75 to the east, and a combination of Millsdale Street and Compton Road to the North. The population was 5,806 at the 2020 census.